{"id":184,"date":"2026-06-14T12:44:32","date_gmt":"2026-06-14T12:44:32","guid":{"rendered":"https:\/\/www.keiopath.med.keio.ac.jp\/?p=184"},"modified":"2026-07-01T23:45:40","modified_gmt":"2026-07-01T23:45:40","slug":"%e7%8c%9c%e9%83%bd%e5%8a%a9%e6%95%99%e3%81%ae%e8%ab%96%e6%96%87%e3%81%8cnature-genetics%e8%aa%8c%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f","status":"publish","type":"post","link":"https:\/\/www.keiopath.med.keio.ac.jp\/?p=184","title":{"rendered":"\u731c\u90fd\u5c1a\u5b50\u52a9\u6559\u306e\u8ad6\u6587\u304cNature Genetics\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u731c\u90fd\u52a9\u6559\u3089\u306e\u8ad6\u6587\u304c\u3001Nature Genetics\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<br>\u672c\u7814\u7a76\u3067\u306f\u3001\u7d44\u7e54\u5b66\u7684\u306b\u7279\u5fb4\u306e\u3042\u308b\u5c0f\u8178\u817a\u816b\u306b\u7740\u76ee\u3057\u3001\u3053\u308c\u307e\u3067\u764c\u3068\u306e\u95a2\u9023\u304c\u77e5\u3089\u308c<br>\u3066\u3044\u306a\u304b\u3063\u305fCOPA\u907a\u4f1d\u5b50\u5909\u7570\u304c\u95a2\u4e0e\u3059\u308b\u3001\u65b0\u305f\u306a\u767a\u304c\u3093\u7d4c\u8def\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<br>\u3053\u306e\u6210\u679c\u306f\u3001\u5e0c\u5c11\u304c\u3093\u3067\u3042\u308b\u5c0f\u8178\u764c\u306e\u767a\u751f\u6a5f\u69cb\u306e\u89e3\u660e\u306b\u3064\u306a\u304c\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u7d30\u80de\u5185<br>\u5c0f\u80de\u8f38\u9001\u304cWNT\u7d4c\u8def\u306e\u5236\u5fa1\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067<br>\u3059\u3002\u672c\u7814\u7a76\u306f\u6176\u61c9\u7fa9\u587e\u5927\u5b66\u533b\u5316\u5b66\u6559\u5ba4\u3001\u540c\u5185\u8996\u93e1\u30bb\u30f3\u30bf\u30fc\u3001\u304a\u3088\u3073\u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3<br>\u30bf\u30fc\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308a\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br>Recurrent COPA mutation drives R-spondin-independent Wnt activation in intestinal<br>tumors.<br>Nature Genetics<br>DOI: 10.1038\/s41588-026-02616-9<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"566\" height=\"245\" src=\"https:\/\/www.keiopath.med.keio.ac.jp\/wp-content\/uploads\/2026\/06\/Picture1.jpg\" alt=\"\" class=\"wp-image-185\" srcset=\"https:\/\/www.keiopath.med.keio.ac.jp\/wp-content\/uploads\/2026\/06\/Picture1.jpg 566w, https:\/\/www.keiopath.med.keio.ac.jp\/wp-content\/uploads\/2026\/06\/Picture1-300x130.jpg 300w\" sizes=\"auto, (max-width: 566px) 100vw, 566px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<br><a href=\"https:\/\/www.keio.ac.jp\/ja\/press-release\/20260615-press-01\">https:\/\/www.keio.ac.jp\/ja\/press-release\/20260615-press-01<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Behind the paper<br>&#8220;Tumor shape matters: discovery of COPA mutation in small intestinal tumors&#8221;<br><a href=\"https:\/\/x.gd\/tyPjd\">https:\/\/x.gd\/tyPjd<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u731c\u90fd\u52a9\u6559\u3089\u306e\u8ad6\u6587\u304c\u3001Nature Genetics\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u7d44\u7e54\u5b66\u7684\u306b\u7279\u5fb4\u306e\u3042\u308b\u5c0f\u8178\u817a\u816b\u306b\u7740\u76ee\u3057\u3001\u3053\u308c\u307e\u3067\u764c\u3068\u306e\u95a2\u9023\u304c\u77e5\u3089\u308c\u3066\u3044\u306a\u304b\u3063\u305fCOPA\u907a\u4f1d\u5b50\u5909\u7570\u304c\u95a2\u4e0e\u3059\u308b\u3001\u65b0\u305f\u306a\u767a\u304c\u3093\u7d4c\u8def\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-184","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www.keiopath.med.keio.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.keiopath.med.keio.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.keiopath.med.keio.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.keiopath.med.keio.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.keiopath.med.keio.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=184"}],"version-history":[{"count":6,"href":"https:\/\/www.keiopath.med.keio.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/184\/revisions"}],"predecessor-version":[{"id":238,"href":"https:\/\/www.keiopath.med.keio.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/184\/revisions\/238"}],"wp:attachment":[{"href":"https:\/\/www.keiopath.med.keio.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.keiopath.med.keio.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=184"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.keiopath.med.keio.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}